Dominik Filipp
Institute of Molecular Genetics of the Czech Academy of Sciences, Prague, Czech Republic

Affiliation:
Institute of Molecular Genetics of The Czech Academy of Sciences

Short Bio:
Education:
1982-1987 RNDr degree in Molecular Biology Genetics, Comenius University, Bratislava

1988-1991 PhD degree (its equivalent), Institute of Molecular Genetics, Moscow, Russia 

Professional experience:
1992 – 1993  Post-Doc Fellow, Lab of Genome Struct and Immune Functions,CIML, Marseille 
1993 – 1994  Assistant Professor, Dept. of Genetics, Comenius University, Bratislava
1994 – 1998  Post-Doctoral Fellow, Department of Immunology, University of Toronto, Toronto,
1998 – 2001  Senior Research Scientist, Gemma Biotechnology Inc., Toronto, Canada 
2001 – 2007  Senior Research Associate, Sunnybrook Research Institute, Toronto, Canada
2007 – present Head of the laboratory of Immunobiology, Institute of Molecular Genetics of the Czech Academy of Sciences, Prague, Czech Republic

An overarching theme of our current research are cellular, molecular and signaling processes underpinning immune homeostasis. That mainly concerns (i) the mechanisms guiding the process of central and peripheral T cell tolerance and autoimmunity; (ii) initiation of T cell activation; (iii) embryonic hematopoiesis, and (iv) the role of Toll-like receptors in these processes.

Selected publications:
  

  • Yamano T, Dobes J, Voboril M., Steinert M, Brabec T, Zietara N, Dobesova M, Ohnmacht C, Laan M, Peterson P, Benes V, Sedlacek R, Hanayama R, Kolar M, Klein L. and Filipp D. Aire-expressing ILC3-like cells in the lymph node display potent APC features. J Exp. Medicine, 2019, Vol.216(5):1027-1037.
  • Balounová J, Šplíchalová I, Dobešová M, Kolář M, Fišer K, Procházka J, Sedláček R, Jurisicova A, Sung, Meritxell Alberich-Jorda and Filipp D. Toll-Like Receptor 2 Expression on c-kit+ Cells Tracks the Emergence of Definitive Hematopoietic Progenitors in a Pre-Circulation Embryo. 2019. Nature Communication, 10:5176.
  • Vobořil M, Brabec T, Dobeš J, Šplíchalová I, Březina J, Čepková A, Dobešová M, Aidarova M, Kubovčiak J, Tsyklauri O, Štěpánek O, Beneš V, Sedláček R, Klein L, Kolář M, and Filipp D. Toll-like receptor signaling in thymic epithelium controls monocyte-derived dendritic cell recruitment and Treg generation. 2020. Nature Communication, 11:2361.
  • Dobes J, Binyamin A, Oftedal B, Goldfarb Y, Kadouri N, Gropper Y, Giladi T, Filipp D, Husebye ES, Abramson J. Aire-expressing ILC3 like cells are essential for induction of Candida-specific Th17 response. 2021. Nature Immunology (provisionally accepted).
  • Vobořil M, Březina J, Brabec T, Dobeš J, Ballek O, Dobešová M, Manning J, Blumberg RS and Filipp D. A model of preferential pairing between epithelial and dendritic cells in thymic antigen transfer. 2021. eLIFE (under revision)