Vítězslav Bryja
Masaryk University, Section of Animal Physiology and Immunology, Brno, Czech Republic

Affiliation:
Department of Experimental Biology, Faculty of Science, Masaryk University, Kamenice 5, 625 00 Brno, Czech Republic
Website: https://www.sci.muni.cz/ofiz/en/bryja/

Short bio:
Vítězslav Bryja, Ph. D. is a professor of Animal Physiology at Faculty of Science of Masaryk University. He earned his degrees at Masaryk University (Master in Molecular biology and genetics), and Charles University in Prague (Ph.D. in Neurosciences). Subsequently, he worked as a postdoctoral researcher at the Department of Molecular Biochemistry and Biophysics at Karolinska Institute, Sweden. 

Upon his return to the Czech Republic, he has worked in the Laboratory of Cytokinetics at the Institute of Biophysics of Academy of Sciences of the Czech Republic and at the Department of Experimental Biology of Faculty of Sciences, Masaryk University where he established his research group in 2007.
Prof. Bryja´s main research interest is to understand the cell signalling cascades with focus on the Wnt signalling pathway in the context of development and cancer pathogenesis. The aim of his research group is to understand how these cascades control asymmetry and cell migration and how these can be exploited as novel therapeutic approaches. Specifically, his research aims to introduce the new casein kinase 1 (CK1) inhibitors into the treatment of chronic lymphocytic leukemia and other cancer types.
Prof. Bryja is an author of 118 scientific publications, an inventor of 4 granted international patents and one of the founders of the spin-off company Casinvent Pharma a.s.

Selected publications:
  

• N. Dani, R. H. Herbst, C. McCabe, G. Green, K. Kaiser, J. Head, J. Cui, F. B. Shipley, A. Jang, D. Dionne, L. Nguyen, C. Rodman, S. J. Riesenfeld, J. Prochazka, M. Prochazkova, R. Sedlacek, F. Zhang, V. Bryja, O. Rozenblatt-Rosen, N. Habib, A. Regev, M. K. Lehtinen (2021): A cellular and spatial map of the choroid plexus across brain ventricles and ages. Cell. 2021. Apr 27;S0092-8674(21)00438-4. doi: 10.1016/j.cell.2021.04.003.
• J. Harnoš, M. C. Alonso Cañizal, M. Jurásek, J. Kumar, C. Holler, A. Schambony, K. Hanáková, O. Bernatík, Z. Zdráhal, K. Gömöryová, T. Gybeľ, T. W. Radaszkiewicz, M. Kravec, L. Trantírek, J. Ryneš, Z. Dave, A. I. Fernández-Llamazares, R. Vácha, K. Tripsianes, C. Hoffmann, V. Bryja (2019): Dishevelled-3 conformation dynamics analyzed by FRETbased biosensors reveals a key role of casein kinase 1. Nat Commun. 2019 Apr 18;10(1):1804. doi: 10.1038/s41467-019-09651-7.
• Janovska P, Verner J, Kohoutek J, Bryjova L, Gregorova M, Dzimkova M, Skabrahova H, Radaszkiewicz T, Ovesna P, Vondalova Blanarova O, Nemcova T, Hoferova Z, Vasickova K, Smyckova L, Egle A, Pavlova S, Poppova L, Plevova K, Pospisilova S, Bryja V. (2018):  Casein Kinase 1 is a Therapeutic Target in Chronic Lymphocytic Leukemia. Blood. 2018 Mar 15; 131(11):1206-1218. doi: 10.1182/blood-2017-05-786947. Epub 2018 Jan 9.
• I. Cervenka, J. Valnohova, O. Bernatik, J. Harnoš, M. Radsetoulal, K. Sedova, K. Hanakova, D. Potesil, M. Sedlackova, A. Salasova, Z. Steinhart, S. Angers, G. Schulte, A. Hampl, Z. Zdrahal and V. Bryja (2016): Dishevelled is a NEK2 substrate controlling dynamics of centrosomal linker proteins. Proc Natl Acad Sci USA. 2016 Aug 16;113(33):9304-9.
• Pospíchalová V., Svoboda J., Dave Z., Kotrbova A., Kaiser K., Klemova D., Ilkovics L., Hampl A., Crha I., Jandakova E., Minar L., Weinberger V., Bryja V. (2015): Simplified protocol for flow cytometry analysis of fluorescently labeled exosomes and microvesicles using dedicated flow cytometer. J Extracell Vesicles. 2015 Mar 31;4:25530. doi: 10.3402/jev.v4.25530.